Regulation of gene expression in human cancers by TRIM24

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Srikanth Appikonda1, Kaushik N Thakkar2, Michelle Craig Barton2

  • 1Department of Epigenetics and Molecular Carcinogenesis, Center for Cancer Epigenetics, Houston, TX 77030, USA.

Drug Discovery Today. Technologies
|October 23, 2016
PubMed

Insights

Tripartite Motif-containing protein 24 (TRIM24) has dual roles in cancer. While mouse studies suggest it

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • Tripartite Motif-containing protein 24 (TRIM24) exhibits multifaceted functions, including E3 ligase activity against p53, histone modification recognition, and nuclear receptor co-regulation.
  • Contrasting evidence exists regarding TRIM24's role in tumorigenesis; mouse models indicate tumor suppression, whereas human studies identify it as an oncogene upon overexpression.

Purpose of the Study:

  • To review the mechanistic roles of TRIM24 in oncogenesis.
  • To explore TRIM24's involvement in metabolic reprogramming within cancer.
  • To highlight the therapeutic potential of targeting aberrant TRIM24 in human cancers.

Main Methods:

  • Literature review of existing studies on TRIM24.
  • Analysis of TRIM24's molecular functions (E3 ligase, histone reader, co-regulator).
  • Synthesis of data on TRIM24's oncogenic and metabolic roles.

Main Results:

  • TRIM24's dual function as a potential tumor suppressor (mouse models) and oncogene (human cancers) is highlighted.
  • Mechanisms linking TRIM24 to cancer development, including p53 regulation and epigenetic modifications, are discussed.
  • TRIM24's contribution to metabolic reprogramming in cancer cells is explored.

Conclusions:

  • Aberrant TRIM24 expression is implicated in human oncogenesis and metabolic reprogramming.
  • TRIM24 represents a promising therapeutic target for various human cancers.

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