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Differential cyclophosphamide sensitivity of suppressor function in Xenopus, the clawed toad
R H Clothier1, Z Last, J D Somauroo
1Department of Human Morphology, University of Nottingham, Queen's Medical Centre, UK.
Developmental and Comparative Immunology
|January 1, 1989
Abstract:
Thymocyte and Splenocyte cultures from in vivo immunised Xenopus were assayed to test their suppressive capacity. Immunisation with TNP-Polyvinylpyrrolidone induced suppression. Suppression induced by the haptenated antigens, TNP-Red blood cells, TNP-Lipopolysaccharide, and TNP-Ficoll affected the anti-TNP antibody response of splenocytes from TNP-PVP immunised animals. Pretreatment with cyclophosphamide revealed both a sensitive and insensitive suppression capacity in Xenopus laevis.