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Updated: Mar 13, 2026

Observation and Analysis of Blinking Surface-enhanced Raman Scattering

Observation and Analysis of Blinking Surface-enhanced Raman Scattering

Published on: January 11, 2018

Mapping for total surface-enhanced Raman scattering to improve its quantification analysis.

Yunfei Tian¹, Peng Wu¹, Qin Liu¹

¹Analytical & Testing Centre, Sichuan University, Chengdu, Sichuan 610064 China.

|October 23, 2016

Summary

This summary is machine-generated.

This study introduces a new total SERS mapping method to overcome challenges in surface-enhanced Raman scattering (SERS) quantification. The novel approach significantly enhances signal stability and extends the linear quantification range for low concentrations.

Keywords:

Mapping analysis Quantification Raman Sampling method Surface-enhanced Raman scattering

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Area of Science:

Analytical Chemistry
Spectroscopy
Materials Science

Background:

Surface-enhanced Raman scattering (SERS) offers ultra-high sensitivity, reaching single-molecule detection.
Existing SERS quantification methods face limitations in stability, repeatability, and linearity, especially at low concentrations.

Purpose of the Study:

To develop a novel quantification strategy for SERS to address current challenges.
To improve the analytical performance of SERS for practical applications.

Main Methods:

A total mapping scheme was employed, integrating all acquired spectra into a single merged spectrum (total SERS spectrum).
Quantification analysis was performed using these total SERS spectra.

Main Results:

The proposed method demonstrated a significant improvement in signal stability, with Relative Standard Deviation (RSD) reduced by at least 50%.
The linear quantification range was extended by one order of magnitude.
Enhanced analytical figures of merit were observed.

Conclusions:

The total SERS mapping quantification strategy offers a promising practical working mode.
This approach effectively enhances the reliability and scope of SERS-based quantification.