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Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Risk of malignant neoplasms in acromegaly: a case-control study.

K Wolinski1, A Stangierski2, K Dyrda2

  • 1Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland. kosma1644@poczta.onet.pl.

Journal of Endocrinological Investigation
|October 23, 2016
PubMed
Summary
This summary is machine-generated.

Patients with acromegaly have a significantly higher risk of developing malignant neoplasms compared to controls. This includes a notable increase in thyroid cancer risk, underscoring the need for vigilant screening.

Keywords:
AcromegalyBreast cancerColon cancerPituitaryThyroid cancer

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Area of Science:

  • Endocrinology
  • Oncology
  • Clinical Medicine

Background:

  • Acromegaly is a chronic condition caused by excess growth hormone and insulin-like growth factor-1.
  • Acromegaly is associated with various complications, including cardiovascular issues, respiratory problems, and an elevated risk of neoplasms.

Purpose of the Study:

  • To investigate the risk of malignant neoplasms in patients diagnosed with acromegaly.
  • To compare the incidence of malignancies in acromegaly patients against a control group.

Main Methods:

  • Analysis of medical records from 200 patients with acromegaly treated between 2005 and 2016.
  • Comparison with a sex- and age-matched control group of 145 patients with prolactinomas or inactive pituitary lesions.

Main Results:

  • Malignant neoplasms were diagnosed in 13.5% of acromegaly patients versus 4.1% in the control group (p=0.003).
  • Thyroid cancer incidence was significantly higher in acromegaly patients (7.0% vs 1.4%, p=0.02).
  • Breast cancer was observed in 5.4% of women with acromegaly, with none in the control group (p=0.02).

Conclusions:

  • Acromegaly patients exhibit a significantly increased prevalence of malignant neoplasms.
  • A fivefold increase in thyroid cancer risk was noted, emphasizing the need for systematic screening.
  • Further research is warranted to identify specific malignancies and quantify risks in acromegaly.