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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Long term evolution of endothelial function during kidney transplantation
Clark Kensinger1, Aihua Bian2, Meagan Fairchild3
1Department of Surgery, Vanderbilt University Medical Center, 1161 21st Avenue South, D4313 MCN, Nashville, TN, 37232, USA.
BMC Nephrology
|October 25, 2016
Summary
Kidney transplantation maintains improved endothelial function long-term, with no significant changes observed up to two years post-transplant. Fibroblast growth factor 23 (FGF-23) levels decreased but showed no association with endothelial function changes.
Area of Science:
- Cardiovascular Health
- Nephrology
- Vascular Biology
Background:
- Endothelial dysfunction is a key factor in atherosclerosis and increased cardiovascular risk in end-stage renal disease patients.
- Kidney transplantation rapidly improves endothelial function, but long-term changes are not well understood.
- Fibroblast growth factor 23 (FGF-23) has been linked to endothelial dysfunction.
Purpose of the Study:
- To evaluate the longitudinal change in endothelial function, measured by flow-mediated dilation (FMD), from 1 to 24 months post-kidney transplantation.
- To investigate the association between FGF-23 levels and changes in FMD following kidney transplantation.
Main Methods:
- Prospective cohort study of 149 kidney transplant recipients.
- Endothelial function (FMD) measured at 1, 12, and 24 months post-transplant.
- FGF-23 levels measured at 1 and 24 months; analyzed using linear mixed-effects models.
Main Results:
- Endothelial function (FMD) remained stable from 1 to 24 months post-transplant (no significant change at 12 or 24 months compared to 1 month).
- FGF-23 levels significantly decreased over time (P=0.024).
- No significant association was found between FGF-23 levels and FMD (P=0.799).
Conclusions:
- Endothelial function is maintained long-term (up to 2 years) after kidney transplantation.
- The study did not find a significant association between FGF-23 and endothelial function post-kidney transplant.
Keywords:
Cardiovascular diseaseCardiovascular risk factorsEndothelial dysfunctionFlow-mediated dilationKidney transplantationMore Related Videos
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