Related Experiment Video

Updated: Mar 13, 2026

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
10:59

Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases

Published on: November 18, 2013

18.9K

The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism

Mengdie Luo1, Daoquan Peng2

  • 1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Lipids in Health and Disease
|October 25, 2016
PubMed

Insights

Apolipoprotein C-III (ApoC-III) plays a key role in triglyceride metabolism and cardiovascular disease development. Novel therapies targeting ApoC-III are emerging to address hypertriglyceridemia and atherosclerosis.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Apolipoprotein C-III (ApoC-III) is a critical regulator of triglyceride-rich lipoprotein metabolism.
  • Elevated ApoC-III levels are linked to hypertriglyceridemia and increased cardiovascular disease (CVD) risk.
  • ApoC-III's role extends beyond lipid metabolism, influencing atherosclerotic lesion formation and other pathological processes in atherosclerosis.

Purpose of the Study:

  • To summarize the multifaceted role of ApoC-III in metabolic and cardiovascular diseases.
  • To highlight the emerging therapeutic strategies for conditions associated with ApoC-III dysregulation.

Main Methods:

  • Review of experimental data and clinical trial findings.
  • Analysis of ApoC-III's involvement in triglyceride metabolism.
  • Investigation of ApoC-III's contribution to atherosclerosis pathogenesis.

Main Results:

  • ApoC-III significantly impacts triglyceride-rich lipoprotein clearance.
  • ApoC-III is implicated in the development and progression of atherosclerotic lesions.
  • Evidence supports ApoC-III's involvement in various pathological processes contributing to atherosclerosis.

Conclusions:

  • Apolipoprotein C-III is a central player in hypertriglyceridemia and atherosclerosis.
  • Novel therapeutic approaches, including antisense technology, show promise for managing ApoC-III-related conditions.

Keywords:
ApolipoproteinsAtherosclerosisGene therapy

More Related Videos

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.6K
The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion06:14

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

3.4K

Related Concept Videos

Lipid Catabolism01:25

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
1.3K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.8K
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
556
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.6K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
730
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
3.2K