Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of DTI Metrics with Structural and Cerebrovascular Disease Imaging Metrics in Idiopathic Normal Pressure Hydrocephalus.

AJNR. American journal of neuroradiology·2026
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy.

Neurobiology of aging·2025
Same author

Non-rapid eye movement sleep slow-wave activity features are associated with amyloid accumulation in older adults with obstructive sleep apnoea.

Brain communications·2024
Same author

Advancing Tau PET Quantification in Alzheimer Disease with Machine Learning: Introducing THETA, a Novel Tau Summary Measure.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2024
Same author

Advancing Tau-PET quantification in Alzheimer's disease with machine learning: introducing THETA, a novel tau summary measure.

Research square·2023

Related Experiment Video

Updated: Mar 13, 2026

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
08:48

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Published on: May 6, 2016

12.9K

Tracking the development of agrammatic aphasia: A tensor-based morphometry study.

Jennifer L Whitwell1, Joseph R Duffy2, Mary M Machulda3

  • 1Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
|October 25, 2016
PubMed
Summary

Neuroimaging reveals that damage to a network including Broca's area, thalamus, and basal ganglia underlies the development of agrammatic aphasia in primary progressive apraxia of speech (PPAOS). Early abnormalities may predict prognosis.

Keywords:
AgrammatismAphasiaApraxia of speechBroca's areaMagnetic resonance imaging

More Related Videos

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

18.5K

Related Experiment Videos

Last Updated: Mar 13, 2026

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia
08:48

Neuronavigation-guided Repetitive Transcranial Magnetic Stimulation for Aphasia

Published on: May 6, 2016

12.9K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.6K
Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
10:15

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

18.5K

Area of Science:

  • Neuroscience
  • Neurology
  • Speech-Language Pathology

Background:

  • Agrammatic aphasia is linked to Broca's area damage, but its necessity and sufficiency are debated.
  • Primary progressive apraxia of speech (PPAOS) offers a unique model to study the emergence of agrammatism.

Purpose of the Study:

  • To investigate the neuroanatomical correlates of developing agrammatic aphasia in PPAOS patients.
  • To identify baseline predictors and longitudinal changes associated with agrammatism onset.

Main Methods:

  • Longitudinal study of 20 PPAOS patients with speech/language assessments and 3T MRI over two years.
  • Tensor-based morphometry and voxel-based morphometry to analyze grey matter atrophy and loss.
  • Comparison of patients who developed agrammatism (progressors) versus those who did not (non-progressors).

Main Results:

  • Progressors were younger at onset and showed more sound distortions.
  • Both groups exhibited atrophy in motor/premotor cortices, basal ganglia, thalamus, and midbrain.
  • Progressors demonstrated significantly greater atrophy rates and baseline grey matter loss in left pars triangularis, thalamus, and putamen.

Conclusions:

  • The development of agrammatic aphasia in PPAOS involves a network including Broca's area, thalamus, and basal ganglia.
  • Pre-symptomatic neuroimaging and clinical findings may aid in predicting agrammatism onset and prognosis.