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Related Experiment Videos

Transvitreal retinochoroidal biopsy.

E Scherfig1, J U Prause, O A Jensen

  • 1Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 1, 1989
PubMed
Summary

Transvitreal biopsies of the retina and choroid are safe and effective for diagnosing various ocular conditions. This minimally invasive technique provides accurate tissue samples without causing significant complications like retinal detachment.

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Area of Science:

  • Ophthalmology
  • Surgical Pathology

Background:

  • Accurate diagnosis of intraocular diseases is crucial for effective treatment.
  • Transvitreal biopsy offers a method for obtaining tissue samples from the posterior segment of the eye.

Purpose of the Study:

  • To evaluate the safety and diagnostic yield of transvitreal biopsies of the retina and choroid.
  • To assess potential complications associated with this surgical approach.

Main Methods:

  • Retina and choroid biopsies were performed in 14 patients using a 20-gauge fine needle via a transvitreal approach.
  • Biopsy site localization was documented using video recording and/or photography.
  • Needle guidance was achieved with a stereotactic micromanipulator or manual control.
  • Laser burns were applied around the biopsy site post-procedure.

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  • Histopathological examination included light microscopy and transmission electron microscopy.

    • Main Results:

    • Diagnoses included malignant melanoma, choroidal hemorrhage, leukemic infiltration, intraretinal fibrosis, atrophic retina, and malignant lymphoma.
    • No retinal detachment or tumor seeding occurred more than 2 years post-biopsy.
    • Two cases of vitreous hemorrhage resolved spontaneously.
    • No visual impairment was attributed to the biopsies.

    Conclusions:

    • Transvitreal biopsy is a safe and effective method for diagnosing a range of posterior segment ocular pathologies.
    • The procedure demonstrated a low complication rate, with no long-term adverse effects on retinal integrity or tumor spread.
    • This technique provides valuable diagnostic material for guiding patient management.