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Effect of physical training on thrombotic tendency in rats: decrease in thrombotic tendency measured by the He-Ne

J Yamamoto1, H Iizumi, R Hirota

  • 1Faculty of Nutrition, Kobe-Gakuin University, Japan.

Haemostasis
|January 1, 1989
PubMed
Summary

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Physical training in rats reduced thrombotic tendency in mesenteric arterioles. This indicates exercise may improve blood flow regulation and reduce clot formation risk.

Area of Science:

  • Physiology
  • Vascular Biology
  • Exercise Science

Background:

  • Thrombotic tendency, or the likelihood of blood clot formation, is a critical factor in cardiovascular health.
  • Physical training is known to influence various physiological systems, but its specific impact on thrombotic tendency requires further elucidation.

Purpose of the Study:

  • To investigate the effects of a consistent physical training regimen on the thrombotic tendency in a rodent model.
  • To determine if exercise influences the formation of occlusive thrombi in the microvasculature.

Main Methods:

  • Rats underwent treadmill exercise (30 min/session, 5 times/week) for 1.5 or 3 months at a submaximal speed (1,400 m/h).
  • Thrombotic tendency was quantified using a He-Ne laser-induced method in mesenteric microvessels, measuring laser irradiations needed to cause blood flow stasis.

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Main Results:

  • A significant increase in the number of laser irradiations required to induce occlusive thrombus formation was observed in arterioles.
  • No significant changes in thrombotic tendency were noted in venules following the training periods.

Conclusions:

  • Regular physical training for 1.5 to 3 months enhances resistance to thrombus formation in rat mesenteric arterioles.
  • Exercise may exert a protective effect against thrombotic events in the arterial microcirculation.