Production and modeling of radioactive gold nanoparticles in Tehran research reactor

Gold has two medically useful radioactive isotopes, ¹⁹⁸Au and ¹⁹⁹Au, for locally irradiating and killing tumor cells. ¹⁹⁸Au radionuclide has been produced through the irradiation of the pure gold via ¹⁹⁷Au(n,γ)¹⁹⁸Au reaction in the Tehran Research Reactor at a thermal neutron flux of 4.5×10¹³ncm^-2s^-1 for the different irradiation times. In this paper, the activity of ¹⁹⁸Au radionuclide has been determined using MCNPX-2.6 and TALYS-1.6 codes and also the theoretical approach. The calculated results were compared with the corresponding experimental values. The calculated results were in good agreement with the experimental data, thus the used codes can be used as a powerful tool to predict and optimize production conditions in reactor.