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Area of Science:

  • Phytochemistry and Pharmacology
  • Natural Product Medicine

Background:

  • Ginger (Zingiber officinale) has a long history of medicinal use.
  • Contains phenolic compounds like gingerol, shogaol, and paradol with antioxidant, anti-tumor, and anti-inflammatory properties.

Purpose of the Study:

  • To review research on gingerols, the main pungent constituents of ginger.
  • To explore their role in modulating signaling pathways for chronic disease amelioration.
  • To describe the physical, chemical, and biological properties of gingerols.

Main Methods:

  • Review of scientific literature focusing on gingerols.
  • Analysis of studies in human and animal models investigating chronic disease prevention and treatment.
  • Examination of the physical, chemical, and biological characteristics of gingerols.

Main Results:

  • Gingerols modulate specific signaling pathways implicated in chronic diseases.
  • Evidence supports the efficacy of gingerols in ameliorating, reversing, or preventing chronic conditions.
  • Gingerols exhibit favorable physical, chemical, and biological properties for medicinal applications.

Conclusions:

  • Ginger and its constituent gingerols are safe and effective as medicinal food derivatives.
  • Potential benefits for preventing and treating various chronic diseases.
  • Valuable resource for healthcare professionals, patients, researchers, and industry.