Related Experiment Video
Updated: Mar 13, 2026
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense
Jing Qu1, Shidong Deng1, Li Li1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
Abstract:
Nine dimeric xanthanolides, pungiolides F-N, and five known analogues, pungiolides A-E, were isolated from fruits of Xanthium chinense. Their structures were elucidated through spectroscopic and electronic circular dichroism (ECD) analyses. Pungiolide F is a xanthanolide dimer with an acyclic linkage. Five of the dimers, pungiolides H, L, A, C and E, exhibited moderate cytotoxicities with IC50 values in the range of 0.90-6.84 μM using taxol as the positive control, which had, by comparison, IC50 values in the range of 0.00118-0.0675 μM. These findings enrich the structural diversity of dimeric sesquiterpene lactones.
