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Updated: Mar 13, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Lipophilic index, kidney function, and kidney function decline.

H Xu1, J Ärnlöv2, B Sandhagen3

  • 1Divisions of Renal Medicine and Baxter Novum, Karolinska Institutet, Stockholm, Sweden.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|October 25, 2016
PubMed
Summary
This summary is machine-generated.

A high lipophilic index (LI), reflecting cell membrane composition, is linked to reduced kidney function and faster decline. This finding suggests LI as a potential indicator for chronic kidney disease (CKD) progression.

Keywords:
CKD progressionFatty acidsFluidityKidney functionKidney function declineLipophilic index

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Area of Science:

  • Nephrology
  • Cardiovascular Health
  • Biochemistry

Background:

  • Unhealthy dietary fats contribute to kidney function decline.
  • Cell membrane phospholipid fatty acid (FA) composition influences membrane fluidity and rheological properties.
  • These properties are associated with kidney damage and may be indicated by the lipophilic index (LI).

Purpose of the Study:

  • To prospectively investigate the association between the lipophilic index (LI) and kidney function.
  • To examine the relationship between LI and the decline in kidney function over time.
  • To assess LI's role in the progression of chronic kidney disease (CKD).

Main Methods:

  • An observational study involving 975 men and women from the Prospective Investigation of Vasculature in Uppsala Seniors.
  • Plasma phospholipid FA composition and cystatin-C estimated glomerular filtration rate (eGFR) were measured.
  • eGFR changes were assessed over 5 years, with participants experiencing a ≥30% reduction defined as CKD progressors.

Main Results:

  • Increased LI showed weak but significant associations with blood viscosity and erythrocyte deformability.
  • Cross-sectional analyses revealed that higher LI was associated with lower eGFR.
  • Longitudinal analyses indicated that higher LI correlated with a faster eGFR decline and increased odds of CKD progression.

Conclusions:

  • A high lipophilic index (LI) is associated with diminished kidney function.
  • Elevated LI is linked to an accelerated decline in kidney function.
  • Higher LI is a predictor of chronic kidney disease (CKD) progression.