Related Experiment Video
Updated: Mar 13, 2026

09:20
Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
Published on: August 10, 2017
9.0K
Development of a Potent and Selective HDAC8 Inhibitor
Oscar J Ingham1, Ronald M Paranal2, William B Smith2
1Department of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
ACS Medicinal Chemistry Letters
|October 25, 2016
Abstract:
A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.

