Modulation of hydrogen sulfide by vascular hypoxia

Hydrogen sulfide (H₂S) has emerged as a key regulator of cardiovascular function. This gasotransmitter is produced in the vasculature and is involved in numerous processes that promote vascular homeostasis, including vasodilation and endothelial cell proliferation. Although H₂S plays a role under physiological conditions, it has become clear in recent years that hypoxia modulates the production and action of H₂S. Furthermore, there is growing evidence that H₂S is cytoprotective in the face of hypoxic insults. This review focuses on the synthesis and signaling of H₂S in hypoxic conditions in the vasculature, and highlights recent studies providing evidence that H₂S is a potential therapy for preventing tissue damage in hypoxic conditions.