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Primary Hyperparathyroidism and Pancreatitis: A Rare Association with Multiple Facets
I Diallo1, C A Fall1, B Ndiaye1
1Department of Internal Medicine and Hepato-Gastroenterology, Hôpital Principal de Dakar, Dakar, Senegal.
International Scholarly Research Notices
|October 25, 2016
Summary
Primary hyperparathyroidism (PHPT) rarely causes pancreatitis. In patients with pancreatitis, elevated calcium levels may indicate PHPT, prompting further investigation for parathyroid disease.
Area of Science:
- Endocrinology
- Gastroenterology
- Nephrology
Background:
- Primary hyperparathyroidism (PHPT) is infrequently linked to pancreatitis.
- Hypercalcemia is a key factor in the development of pancreatitis associated with PHPT.
Purpose of the Study:
- To report five cases of pancreatitis that revealed primary hyperparathyroidism.
- To highlight the association between pancreatitis and PHPT.
Main Methods:
- Retrospective study over 4 years.
- Inclusion of patients admitted to ICU or gastroenterology for acute or chronic pancreatitis revealing PHPT.
Main Results:
- Five female patients (mean age 54) presented with pancreatitis revealing PHPT.
- All cases showed hypercalcemia; four had elevated parathyroid hormone.
- Four patients had favorable outcomes after parathyroid surgery; one severe AP case resulted in death.
Conclusions:
- Pancreatitis is a rare manifestation of hyperparathyroidism.
- Elevated or normal calcemia in pancreatitis patients warrants investigation for PHPT.
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