[Multi-organ lesions of C57BL/6J mouse models with immune-mediated Sjogren's syndrome]

Objective To observe multi-organ damages at different stages in immune-mediated mouse models of Sjogren's syndrome. Methods Eighty C57BL/6J mice were divided randomly into 2 groups, a blank control group and a model group. Sjogren's syndrome was induced in the 40 mice in the latter group by immune injury. Every 10 mice were killed at 4, 6, 8 and 10 weeks. The submandibular gland, thymus, lung, spleen and kidney were isolated under sterile condition. HE staining was used to observe the pathological changes of the organs under a light microscope. Results Compared with the blank control group, the organs of the model group appeared obvious pathological changes since the 6th weeks, which were characterized by submandibular gland damage and infiltrating lymphocytes, as well as the damages of the lung, kidney, spleen and other organs. The most severe damage was observed at the 8th and 10th week. Conclusion C57BL/6J mouse models of Sjogren's syndrome show the characteristics of multi-system damage, especially obvious at the 8th weeks.