Hepatic mitochondrial membranolysis repairing by spermidine

Hepatic mitochondrial membrane lysis is caused due to excess vitamin A, has been repaired by spermidine. This fact has been proved by estimating membrane proteins, lipids, phospholipase A2 activity and membrane phospholipids of rat liver mitochondria by studying the effect of spermidine on membranolytic effect of excess vitamin A. Spermidine has been found to inhibit the activity of phospholipase A2 and thus stabilize the hepatic mitochondrial membranes in the hypervitaminoic A model, that is to say, the spermidine tries to bring down the enormously elevated levels of phospholipase A2 by administration of excess vitamin A in rats.