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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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Coronary artery disease detected by coronary computed tomography angiography is associated with red cell distribution

Emir Karaçağlar1, Uğur Bal2, Senem Hasırcı2

  • 1Department of Cardiology, Başkent University Faculty of Medicine, Ankara, Turkey. dremirkaracaglar@hotmail.com.

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|October 25, 2016
PubMed

Insights

Higher red blood cell distribution width (RDW) is linked to coronary artery disease (CAD). This study found elevated RDW independently predicts CAD detected by coronary computed tomography angiography (CCTA) in patients without prior diagnosis.

Area of Science:

  • Cardiology
  • Medical Diagnostics

Background:

  • Red blood cell distribution width (RDW) is an indicator of erythrocyte size variation.
  • Elevated RDW has been associated with the severity of coronary artery disease (CAD).

Purpose of the Study:

  • To retrospectively investigate the association between CAD diagnosed via coronary computed tomography angiography (CCTA) and RDW levels.
  • To determine if RDW is an independent predictor of CAD in patients presenting with angina-like chest pain.

Main Methods:

  • Retrospective analysis of 291 patients who underwent 16-slice CCTA for chest pain evaluation.
  • Exclusion criteria were applied to refine the study cohort.
  • Clinical data, CAD risk factors, and RDW values were collected and analyzed.

Main Results:

  • Patients with CAD exhibited significantly higher RDW levels compared to those with normal coronary arteries (15.50±1.57 vs. 14.80±1.41, p=0.001).
  • Diabetes mellitus, hypertension, and smoking history were more prevalent in the CAD group.
  • Multivariate analysis identified RDW (OR: 1.352), age (OR: 1.063), and smoking history (OR: 2.672) as independent predictors of CAD detected by CCTA.

Conclusions:

  • Elevated RDW is independently associated with the presence of CAD diagnosed by CCTA in patients without a known history of the disease.
  • Further research is recommended to elucidate the precise role of RDW in cardiovascular risk stratification.
Abstract

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