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Related Concept Videos

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Mar 13, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Retinal oxygen saturation before and after glaucoma surgery.

Eri Nitta1, Kazuyuki Hirooka1, Takeru Shimazaki1

  • 1Department of Ophthalmology, Kagawa University Faculty of Medicine, Kagawa, Japan.

Acta Ophthalmologica
|October 25, 2016
PubMed
Summary

Glaucoma surgery significantly reduced intraocular pressure and increased retinal venous oxygen saturation. Retinal arteriolar oxygen saturation remained unchanged after glaucoma surgery, indicating a specific effect on venous blood oxygen levels.

Keywords:
glaucoma surgeryintraocular pressureoxygen saturationretinal oximetry

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Area of Science:

  • Ophthalmology
  • Medical Physiology

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Effective management of glaucoma often involves surgical intervention to reduce intraocular pressure (IOP).
  • The impact of glaucoma surgery on ocular hemodynamics, specifically retinal oxygen saturation, requires further investigation.

Purpose of the Study:

  • To compare retinal vessel oxygen saturation before and after glaucoma surgery.
  • To investigate the relationship between reduced intraocular pressure and changes in retinal oxygen saturation post-surgery.

Main Methods:

  • Retinal oxygen saturation was measured non-invasively using spectrophotometric retinal oximetry in glaucoma patients.
  • Measurements were taken in retinal arterioles and venules 1 day before and 10 days after glaucoma surgery.
  • Surgical procedures included trabeculectomy, EX-PRESS shunt implantation, and trabeculotomy.

Main Results:

  • Glaucoma surgery led to a significant decrease in intraocular pressure (IOP) from 19.8 ± 7.7 mmHg to 9.0 ± 5.7 mmHg (p < 0.001).
  • Retinal arteriolar oxygen saturation showed no significant change after surgery (104.7 ± 10.6% vs. 105.4 ± 9.3%, p = 0.58).
  • Retinal venular oxygen saturation significantly increased from 54.9 ± 7.4% to 57.4 ± 5.7% (p = 0.01) post-surgery.

Conclusions:

  • Glaucoma surgery effectively lowers intraocular pressure.
  • The reduction in IOP following glaucoma surgery positively impacts retinal venous oxygen saturation.
  • These findings suggest that changes in venous oxygen saturation may be a sensitive indicator of hemodynamic alterations after glaucoma surgery.