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Location, Dissection, and Analysis of the Murine Stellate Ganglion
Published on: December 22, 2020
[Left cardiac sympathetic denervation in congenital ventricular arrythmias: initial experience]
X Tarrado1, G Sarquella-Brugada2, L Saura1
1Servicio de Cirugía Pediátrica. Hospital Sant Joan de Déu-Clínic. Universidad de Barcelona.
Background:
Left cardiac sympathetic denervation (LCSD) has been proposed as a second-line therapy for potentially lethal ventricular arrythmia with no response to the gold standard treatment with beta-blockers. It has been used mainly in channelopathies such as long QT syndrome (LQTS) and polymorphic cathecolaminergic ventricular tachycardia (PCVT).
Aim:
Analizing our preliminary experience in the treatment of congenital ventricular arrythmia with thoracoscopic LCSD.
Material And Methods:
We have reviewed the first 5 LCSD performed in the last two years (2011-2013) to 5 female patients with a mean age of 8 years (1 month-15 years). The underlying disease was the LQTS in three and the PCVT in two.
Results:
Selective contralateral bronchial intubation was used in two cases and double-lumen tube in three. We performed in all cases T1 sympathicolysis, denervation of T2 ganglion and sympathicolysis of T3 and T5 levels. No intraoperatory nor postoperatory complications were observed. In four cases ventricular tachycardia disappeared after the procedure and in one case, although they did not completely disappeared, they could be better controled on medical therapy. Ventricular extrasystoles reappeared 17 months after the procedure in one PCTV case, but disappeared completely after T1-T5 left sympathectomy completion. With a mean follow-up time of 20 months, all patients are sympthom-free and continue on betablocker oral therapy.
Conclusions:
Thoracoscopic DCSI is a safe and effective therapy for prevention of severe congenital ventricular arrythmias.
Insights
Left cardiac sympathetic denervation (LCSD) effectively treats congenital ventricular arrhythmias unresponsive to beta-blockers. This thoracoscopic procedure is safe and provides long-term symptom relief for patients with LQTS and PCVT.
Area of Science:
- Cardiology
- Thoracic Surgery
- Medical Devices
Background:
- Left cardiac sympathetic denervation (LCSD) is a second-line therapy for potentially lethal ventricular arrhythmias.
- It is primarily used for channelopathies like long QT syndrome (LQTS) and polymorphic catecholaminergic ventricular tachycardia (PCVT) when beta-blockers fail.
Observation:
- A preliminary experience of 5 thoracoscopic LCSD procedures in pediatric patients (mean age 8 years) with congenital ventricular arrhythmias.
- Three patients had LQTS, and two had PCVT.
Findings:
- The thoracoscopic LCSD procedure involved T1 sympathicolysis, T2 ganglion denervation, and T3/T5 sympathicolysis.
- No intraoperative or postoperative complications occurred. Ventricular tachycardia resolved in four patients and improved in one.
- One patient experienced recurrence of ventricular extrasystoles but responded to extended sympathectomy. All patients remained symptom-free at a mean 20-month follow-up.
Implications:
- Thoracoscopic LCSD is a safe and effective treatment for severe congenital ventricular arrhythmias.
- This minimally invasive approach offers a viable alternative for refractory cases.
- Long-term symptom control and improved quality of life are achievable.
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