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Related Experiment Video

Updated: Mar 13, 2026

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Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis.

Jeri W Nieves1, Chris Gennings2, Pam Factor-Litvak3

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Higher intake of antioxidants and carotenes from fruits and vegetables is linked to better function in people with amyotrophic lateral sclerosis (ALS). This highlights the importance of a nutrient-rich diet for ALS management.

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Area of Science:

  • Neurology
  • Nutritional Science
  • Epidemiology

Background:

  • Growing interest in nutrition's impact on amyotrophic lateral sclerosis (ALS) pathogenesis and progression.
  • Understanding the relationship between nutrient intake and ALS outcomes is crucial for patient care.

Purpose of the Study:

  • To evaluate associations between specific nutrients, nutrient groups, and ALS functional and respiratory status at diagnosis.
  • To explore the role of dietary patterns in early-stage ALS.

Main Methods:

  • Cross-sectional analysis of 302 patients with ALS from the ALS Multicenter Cohort Study of Oxidative Stress.
  • Nutrient intake assessed via a modified Block Food Frequency Questionnaire (FFQ).
  • ALS function measured by ALS Functional Rating Scale-Revised (ALSFRS-R); respiratory function by forced vital capacity (FVC).

Main Results:

  • Higher intake of antioxidants and carotenes from vegetables correlated with better ALSFRS-R scores and FVC.
  • Empirically weighted indices of "good" micronutrients and food groups showed positive associations with ALSFRS-R and FVC (P < .001).
  • Exploratory analyses indicated significant positive associations for selected vitamins with ALSFRS-R and FVC (P = .02).

Conclusions:

  • Antioxidants, carotenes, fruits, and vegetables are associated with better baseline ALS function.
  • Weighted quantile sum regression is a useful method for evaluating dietary impact in ALS.
  • Promoting fruit and vegetable consumption is recommended for individuals with ALS due to their high antioxidant and carotene content.