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Association between irisin and major chronic diseases: a review
M C Gouveia1, J P Vella, F R Cafeo
1General Practice Department, Faculdade de Medicina do ABC, Santo Andre, São Paulo, Brazil. mrbacci@yahoo.com.
European Review for Medical and Pharmacological Sciences
|October 25, 2016
Summary
Irisin, a muscle protein, is linked to various diseases. This review found irisin levels correlate with obesity, diabetes, kidney disease, and cancer prognosis, suggesting its role in disease development.
Area of Science:
- Endocrinology and Metabolism
- Molecular Biology
- Oncology
Background:
- Irisin is a myokine with emerging physiological roles.
- Its connection to various metabolic and non-metabolic diseases is under investigation.
- Understanding irisin's function may offer insights into disease pathogenesis.
Purpose of the Study:
- To systematically review the association between irisin levels and the prognosis of obesity, diabetes mellitus, non-alcoholic steatohepatitis, chronic kidney disease, and cancer.
Main Methods:
- Systematic literature search using "irisin" as a keyword in Medline.
- Inclusion criteria: human studies, English language, with abstracts.
Main Results:
- Higher irisin associated with better glycemic control post-weight loss in obesity.
- Lower irisin linked to macrovascular complications in diabetes.
- Irisin levels decrease with CKD stage, associated with insulin resistance and sarcopenia.
- Irisin demonstrated anti-proliferative effects on breast cancer cells.
- Irisin concentration correlated with osteoporotic fracture history.
Conclusions:
- Irisin concentrations show a relationship with the development and prognosis of the studied conditions.
- Irisin may serve as a potential biomarker in metabolic and oncological diseases.
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