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Multimodal approach of advanced gastric cancer: based therapeutic algorithm
S Berretta1, M Berretta, F Fiorica
1Department of Surgery, University of Catania, Catania, Italy. mberretta@cro.it.
European Review for Medical and Pharmacological Sciences
|October 25, 2016
Summary
Gastric cancer (GC) remains a leading cause of cancer death globally. Understanding prognostic factors and predictive responses is crucial for effective targeted therapy and improving patient survival through multidisciplinary approaches.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Gastric cancer (GC) is a significant global health challenge, ranking as the third leading cause of cancer mortality worldwide.
- Despite advances in treatment, the prognosis for GC often remains poor due to its complex biological characteristics.
Purpose of the Study:
- To review current literature on prognostic aspects and predictive factors for therapy response in gastric cancer.
- To analyze therapeutic approaches including surgery and radiotherapy for locally, locally advanced, and advanced GC.
Main Methods:
- Comprehensive literature review of recently published English studies.
- Analysis of data on prognostic factors and predictive response to therapy.
- Evaluation of surgical and radiotherapeutic strategies.
Main Results:
- Identifying key prognostic factors and predictive markers is essential for tailoring treatment strategies in the era of targeted therapy.
- A multidisciplinary approach combining chemotherapy, surgery, and radiotherapy demonstrates potential for improved GC prognosis.
Conclusions:
- Personalized treatment strategies based on biological insights are paramount for improving outcomes in gastric cancer.
- Integrated treatment modalities offer a promising avenue for enhancing survival rates in patients with locally, locally advanced, and advanced gastric cancer.
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