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Updated: Mar 13, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
Published on: April 2, 2020
Knockdown of long noncoding RNA AB073614 inhibits glioma cell proliferation and migration via affecting
1Department of Neurosurgery, Linyi People's Hospital, Linyi, Shandong, China. lj9lj987@163.com.
Objective:
This study was aimed to explore the role of long noncoding RNA (lncRNA) AB073614 and its potential mechanisms in the glioma development.
Materials And Methods:
Expression levels of lncRNA AB073614 in glioma tissues and glioma cell lines were evaluated by quantitative real-time PCR (qRT-PCR). MTT assays were conducted to explore the impact of AB073614 down-regulation on the proliferation of human glioma cells. The effects of AB073614 knockdown on cell proliferation and migration were evaluated by in vitro assays. EMT-related molecular markers expression level was detected by qRT-PCR assay and Western blot analysis.
Results:
We confirmed that AB073614 was significantly upregulated in glioma tissues and cell lines (p < 0.01). In vitro studies demonstrated that knockdown of AB073614 inhibits U251 cell proliferation and migration. Moreover, knockdown of AB073614 could inhibit epithelial-mesenchymal transition (EMT) phenotype in glioma cells.
Conclusions:
AB073614 functions as a tumor promoter in glioma. This finding may provide a therapeutic approach for future treatment of glioma.
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