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Alkyl Glucosides.
Maisa Alfalah1, Camille Loranger, Denis Sasseville
1From the *Division of Dermatology, National Guard Hospital, Riyadh, Saudi Arabia; and †Division of Dermatology, McGill University Health Centre, Montreal, Quebec, Canada.
Dermatitis : Contact, Atopic, Occupational, Drug
|October 25, 2016
Summary
Alkyl glucosides, like decyl glucoside, are eco-friendly cosmetic ingredients. However, they are increasingly causing allergic contact dermatitis, necessitating careful patch testing for diagnosis.
Area of Science:
- Dermatology
- Cosmetic Science
- Allergology
Background:
- Alkyl glucosides are plant-derived surfactants used in cosmetics for their eco-friendly properties.
- Despite a history of low irritancy, allergic contact dermatitis cases linked to alkyl glucosides have risen since the early 2000s.
- Decyl glucoside is identified as a significant allergen in products like Tinosorb M.
Purpose of the Study:
- To investigate the increasing incidence of allergic contact dermatitis caused by alkyl glucosides.
- To highlight the role of decyl glucoside as a common allergen in cosmetic products.
- To emphasize the importance of comprehensive patch testing for suspected alkyl glucoside allergy.
Main Methods:
- Review of reported cases of allergic contact dermatitis.
- Analysis of sensitization rates to decyl glucoside by dermatology groups.
- Clinical observation of cross-reactivity patterns among different glucosides.
Main Results:
- A notable increase in sensitization rates to decyl glucoside has been observed.
- Decyl glucoside is frequently implicated in allergic contact dermatitis, often as a "hidden" allergen.
- Cross-reactions between different alkyl glucosides occur but are not universal.
Conclusions:
- Decyl glucoside is an emerging allergen responsible for a growing number of allergic contact dermatitis cases.
- The "hidden" nature of decyl glucoside in formulations can complicate diagnosis.
- Patch testing with multiple alkyl glucosides is crucial for accurate diagnosis and management of allergic contact dermatitis.
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