Related Experiment Video
Updated: Mar 13, 2026
08:02
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
5.2K
Alkyl Glucosides in Contact Dermatitis.
Camille Loranger1, Maisa Alfalah, Marie-Christine Ferrier Le Bouedec
1From the *Division of Dermatology, McGill University Health Centre, Montreal, Quebec, Canada, †Division of Dermatology, National Guard Hospital, Riyadh, Saudi Arabia; and ‡Service de Dermatologie, Centre Hospitalier Universitaire Estaing, Clermont-Ferrand, France.
Dermatitis : Contact, Atopic, Occupational, Drug
|October 25, 2016
Summary
Alkyl glucosides, used in cosmetics, are increasingly linked to allergic contact dermatitis. Most reactions are to lauryl and decyl glucosides, emergent allergens found in various personal care products.
Area of Science:
- Dermatology
- Cosmetic Science
- Allergology
Background:
- Alkyl glucosides are mild surfactants derived from natural, renewable sources, gaining popularity in the cosmetic industry.
- These surfactants are incorporated into both rinse-off (shampoos, cleansers) and leave-on (moisturizers, sunscreens) cosmetic products.
Purpose of the Study:
- To review the chemistry and sources of exposure to alkyl glucosides.
- To summarize reported cutaneous adverse effects of alkyl glucosides, focusing on allergic contact dermatitis.
- To highlight alkyl glucosides as emergent allergens in cosmetic products.
Main Methods:
- Literature review of published cases of allergic contact dermatitis.
- Analysis of data from patch testing centers.
- Examination of the chemical properties and applications of alkyl glucosides.
Main Results:
- Numerous cases of allergic contact dermatitis to lauryl and decyl glucosides have been reported over the past 15 years.
- Decyl glucoside acts as a hidden allergen in sunscreen formulations like Tinosorb M, causing most reported reactions.
- Alkyl glucosides are identified as emergent allergens in cosmetic products.
Conclusions:
- Alkyl glucosides, despite their "green" profile, pose a risk of allergic contact dermatitis.
- Decyl glucoside is a significant cause of allergic contact dermatitis, often overlooked in product formulations.
- Increased awareness and patch testing are crucial for managing alkyl glucoside-induced allergies.
Related Concept Videos
01:30Drug Toxicity: Allergic Reactions
85
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
85
01:23Hand hygiene
6.4K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
6.4K
01:19Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
738
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
Acarbose and miglitol are...
738
01:24Phase II Reactions: Glucuronidation
2.0K
Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...
2.0K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.8K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.8K
01:06Oral Hypoglycemic Agents: Glinides
804
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
804