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Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

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Scleroderma and dentistry: Two case reports.

Shantanu Dixit¹, Chaithra Kalkur², Atul P Sattur³

¹Department of Oral Medicine and Radiology, Dhulikhel hospital, Kathmandu University School of Medical Sciences, Dhulikhel, Nepal. drshantanudixit@gmail.com.

Journal of Medical Case Reports

|October 26, 2016

Summary

This summary is machine-generated.

Scleroderma, a connective tissue disease, presents varied manifestations. This study details two rare cases: morphea with Parry-Romberg syndrome and progressive systemic sclerosis, highlighting diagnostic importance.

Keywords:

CREST syndrome Localized scleroderma Morphea Parry–Romberg syndrome Raynaud’s phenomenon Systemic sclerosis

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Area of Science:

Rheumatology and Connective Tissue Diseases
Dermatology and Cutaneous Manifestations
Oral Medicine and Pathology

Background:

Scleroderma is a chronic connective tissue disorder of unknown etiology.
Characterized by excessive extracellular matrix deposition, leading to vascular disturbances and tissue hypoxia.
Manifests as skin, subcutaneous tissue, muscle, and internal organ atrophy, classified into localized (morphea) and diffuse (systemic) types.

Observation:

Case 1: A 20-year-old male with facial asymmetry, speech difficulty, and taste loss, diagnosed with mixed morphea and Parry-Romberg syndrome.
Case 2: A 53-year-old female with decreased mouth opening, sclerotic skin, xerostomia, and candidiasis, diagnosed with progressive systemic sclerosis.

Findings:

Serological tests revealed specific autoantibodies (anti-dsDNA, anti-mitochondria, anti-centromere B, Scl-70, Ro-52).
Radiological and biopsy findings confirmed morphea and progressive systemic sclerosis.
Parry-Romberg syndrome association with morphea was observed in one case.

Implications:

Emphasizes the critical role of general examination in diagnosing rare systemic diseases like scleroderma.
Highlights the importance of general dentists in managing patients with scleroderma.
Underscores the need for awareness of scleroderma's diverse clinical presentations in routine practice.