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Updated: Oct 11, 2026
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo
Karin Hock1, Johannes Laengle1, Irina Kuznetsova1
1Department of Surgery, Medical University of Vienna, Vienna, Austria.
Background:
Interleukin-15 has become a promising molecule in the context of eliciting an effective, antitumor immune response because it is able to stimulate cells of the innate and adaptive immune system.
Methods:
We generated an interleukin-15-expressing oncolytic influenza A virus for the treatment of an established murine tumor model.
Results:
Our oncolytic influenza A virus produced large amounts of interleukin-15 and induced proliferation and activation of human T cells in vitro. Intraperitoneal administration increased the amount of mouse natural killer cells and effector memory T cells, as well as T cell reactivity in vivo. Moreover, intratumoral injection induced a profound decrease in growth of established tumors in mice and increased the amount of tumor-infiltrating T cells and natural killer cells.
Conclusion:
We established a stable, IL-15-producing oncolytic influenza A virus with promising immunostimulatory and antitumor attributes.
