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Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological

E V Shchegol'kov1, I V Shchur1, Ya V Burgart1

  • 1Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Science, S. Kovalevskoy Str., 22, Ekaterinburg 620990 Russia.

Bioorganic & Medicinal Chemistry
|October 26, 2016
PubMed

Keywords:
Anti-inflammatory and analgesic activitiesCOX-1 inhibitionMolecular dockingNucleophilic substitutionPermeabilityPolyfluoronated salicylatesToxicityortho-Methoxylation

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