Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

645
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
645
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

5.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Agmatine: An Emerging Approach for Neuroprotection in Recurrent Ischemic Stroke Events in a Murine Model.

Drug development research·2024
Same author

Antiallodynic Activity of Ceftriaxone and Clavulanic Acid in Acute Administration is Associated with Serum TNF-α Modulation and Activation of Dopaminergic and Opioidergic Systems.

Drug development research·2017
See all related articles

Related Experiment Video

Updated: Mar 13, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

557

Neuroimmunological interactions in stroke.

M A Sotomayor-Sobrino1, A Ochoa-Aguilar1, L A Méndez-Cuesta1

  • 1Laboratorio de Biomembranas, Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, México.

Neurologia
|October 26, 2016
PubMed
Summary

Stroke triggers neuroinflammation, worsening brain damage. Modulating the immune system offers a promising therapeutic strategy for stroke patients, potentially improving outcomes and recovery.

Keywords:
IctusInflamaciónInflammationNeurogenesisNeurogénesisNeuroprotecciónNeuroprotectionPenumbraStroke

More Related Videos

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.4K
A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

10.3K

Related Experiment Videos

Last Updated: Mar 13, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

557
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

Published on: February 12, 2016

36.4K
A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

10.3K

Area of Science:

  • Neuroscience
  • Immunology
  • Pathophysiology

Background:

  • Stroke is a leading global cause of death, with increasing incidence due to longer life expectancy.
  • Current treatment options for stroke are limited, with no clinically effective drugs available.

Purpose of the Study:

  • To explore the role of neuroinflammation in stroke progression.
  • To investigate immune modulation as a potential therapeutic strategy for stroke.

Main Methods:

  • Review of clinical evidence on post-stroke neurochemical changes.
  • Analysis of the impact of pro-inflammatory and anti-inflammatory cytokines on brain damage and repair.

Main Results:

  • Stroke induces neurochemical changes, including energy depletion, free radical synthesis, and calcium accumulation.
  • Immune response, particularly inflammation mediated by TNF, exacerbates brain damage.
  • Anti-inflammatory cytokines like IL-10 and IL-4 demonstrate neuroprotective effects and promote neurogenesis.

Conclusions:

  • Understanding the immune-nervous system interplay is crucial for stroke research.
  • Immune modulation presents a promising avenue for novel diagnostic, prognostic, and therapeutic strategies in stroke care.