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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Association between vascular calcification assessed by simple radiography and non-fatal cardiovascular events in

Vaida Petrauskiene1, Ruta Vaiciuniene1, Inga Arune Bumblyte1

  • 1Medical academy, Lithuanian University of Health sciences, Eiveniu g. 2A, Kaunas 50009, Lithuania; Nephrology department, Hospital of Lithuanian University of Health sciences Kaunas Clinics, Kaunas 50009, Lithuania.

Nephrologie & Therapeutique
|October 26, 2016
PubMed

Insights

Vascular calcification (VC) in hemodialysis patients, assessed by a simple score, independently predicts cardiovascular events. Early detection through this inexpensive method may improve patient outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Vascular calcification (VC) is a significant contributor to cardiovascular mortality in hemodialysis (HD) patients.
  • Current recommendations for VC screening vary, and its potential for prevention and reversal is debated.
  • The study aimed to assess the clinical significance of a simple vascular calcification score (SVCS) in HD patients.

Purpose of the Study:

  • To evaluate the significance of the simple vascular calcification score (SVCS) derived from plane radiographic films.
  • To determine the association between SVCS and non-fatal cardiovascular events in patients undergoing chronic HD.
  • To investigate VC as a predictor of cardiovascular outcomes in the HD population.

Main Methods:

  • A cohort of 95 prevalent HD patients was studied.
  • Clinical data and laboratory results were collected from medical records.
  • SVCS was calculated, and patients were monitored for new non-fatal cardiovascular events.

Main Results:

  • Patients with SVCS ≥ 3 showed a significantly higher incidence of non-fatal cardiovascular events (26.3%) compared to those with SVCS < 3 (7.8%).
  • Multivariate analysis identified VC, hyperphosphatemia, and lower ejection fraction as independent predictors of cardiovascular events.
  • VC in hands was also associated with an increased rate of cardiovascular events.

Conclusions:

  • Simple vascular calcification score (SVCS) assessed via a straightforward radiological method is an independent predictor of cardiovascular events in HD patients.
  • This inexpensive screening tool can identify high-risk individuals for cardiovascular events.
  • The findings support the utility of SVCS in managing cardiovascular risk in chronic HD patients.
Abstract

Keywords:
Ca-P metabolism disordersCardiovascular eventsVascular calcification

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