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Related Experiment Videos

Testicular feminization in a cat.

V N Meyers-Wallen1, J D Wilson, J E Griffin

  • 1Section of Medical Genetics and National Referral Center--Animal Models of Human Genetic Disease, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104.

Journal of the American Veterinary Medical Association
|September 1, 1989
PubMed
Summary

Testicular feminization in cats, an X-linked inherited disorder, affects genetic males lacking functional androgen receptors. This results in female external genitalia despite the presence of testes.

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Area of Science:

  • Veterinary Genetics
  • Reproductive Biology
  • Endocrinology

Background:

  • Testicular feminization is an inherited condition affecting androgen receptor function.
  • Genetic males with this syndrome fail to masculinize due to androgen insensitivity.

Observation:

  • A domestic cat presented with the external characteristics of a female.
  • Surgical examination revealed abdominal testes but no Müllerian or wolffian derivatives.
  • Histologic analysis confirmed testicular tissue.

Findings:

  • Karyotyping showed a normal male chromosome constitution (38,XY).
  • Fibroblast cultures from genital skin exhibited undetectable dihydrotestosterone binding, indicating a nonfunctional androgen receptor.
  • Pedigree analysis suggested an X-linked inheritance pattern.

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Implications:

  • This diagnosis in cats mirrors the X-linked inheritance seen in other mammals.
  • Accurate diagnosis and genetic counseling are crucial for managing this disorder.
  • Reducing the prevalence of testicular feminization in feline populations is advocated.