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Related Concept Videos

Model Approaches for Pharmacokinetic Data: Physiological Models01:15

Model Approaches for Pharmacokinetic Data: Physiological Models

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Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
331
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
434
Physiological Pharmacokinetic Models: Assumption with Protein Binding01:13

Physiological Pharmacokinetic Models: Assumption with Protein Binding

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Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
326
Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

2.4K
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
2.4K
Pharmacokinetic–Pharmacodynamic Relationship: Model Components01:14

Pharmacokinetic–Pharmacodynamic Relationship: Model Components

86
Pharmacokinetic-pharmacodynamic (PK–PD) modeling is essential in drug development and clinical pharmacology. It provides a quantitative framework to predict drug behavior and response over time. This approach integrates pharmacokinetics (PK), which describes the drug's absorption, distribution, metabolism, and excretion, with pharmacodynamics (PD), which characterizes the drug’s biological effects and mechanisms of action.The disposition kinetics of a drug determine its plasma...
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Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

367
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
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Related Experiment Video

Updated: Mar 13, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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[Physiolgically-based pharmacokinetics:Theory and examples.]

Takahiro Ishimoto1, Yukio Kato1

  • 1Laboratory of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University, Japan.

Clinical Calcium
|October 26, 2016
PubMed
Summary

Physiologically-based pharmacokinetics (PBPK) quantifies drug concentration in the body, aiding understanding of therapeutic outcomes and side effects. This review explains PBPK principles and applies them to osteoporosis drugs.

Area of Science:

  • Pharmacology
  • Pharmacokinetics
  • Drug Metabolism and Transport

Background:

  • Drug efficacy and side effects are often linked to drug concentration in the body.
  • Physiologically-based pharmacokinetics (PBPK) offers a quantitative framework to understand drug disposition.
  • Subjective factors can influence drug efficacy, but PBPK can help predict pharmacological events.

Purpose of the Study:

  • To summarize the fundamental principles of PBPK.
  • To elucidate the factors influencing drug concentration within the body.
  • To demonstrate the application of PBPK in predicting drug concentrations, using osteoporosis drugs as examples.

Main Methods:

  • Review of PBPK principles and their application in drug development.
  • Analysis of factors determining drug concentration (e.g., absorption, distribution, metabolism, excretion).

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  • Illustrative examples of PBPK properties for selected osteoporosis medications.

    • Main Results:

    • PBPK provides a mechanistic understanding of drug behavior in the body.
    • Key physiological and drug-specific parameters dictate drug concentration.
    • PBPK modeling can predict drug exposure and inform therapeutic strategies.

    Conclusions:

    • PBPK is a valuable tool for quantitatively assessing drug pharmacokinetics.
    • Understanding PBPK aids in predicting drug efficacy and potential side effects.
    • The principles discussed are broadly applicable, with specific relevance to osteoporosis drug management.