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Air pollution, epigenetics, and asthma.

Hong Ji1, Jocelyn M Biagini Myers2, Eric B Brandt2

  • 1Division of Asthma Research, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. MLC 7037, Cincinnati, OH 45229 USA ; Pyrosequencing lab for Genomic and Epigenomic research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|October 26, 2016
PubMed
Summary
This summary is machine-generated.

Traffic-related air pollution (TRAP) exposure is linked to asthma. New research explores epigenetic changes and advanced methods to understand and combat TRAP-induced asthma.

Keywords:
AsthmaEpigeneticsTraffic pollution

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Area of Science:

  • Environmental Health Science
  • Molecular Biology
  • Epidemiology

Background:

  • Traffic-related air pollution (TRAP) is a significant environmental exposure linked to asthma development, persistence, and exacerbation.
  • Many populations, including children in school environments, are disproportionately exposed to TRAP.
  • Understanding the epigenetic mechanisms underlying TRAP's impact on asthma is crucial for public health.

Approach:

  • This review summarizes recent findings on epigenetic mechanisms of TRAP-induced asthma.
  • It highlights the need for innovative methods to accurately assess and quantify TRAP exposure.
  • The review discusses advancements in molecular asthma phenotyping and exposure assessment.

Key Points:

  • Epigenetic modifications offer new insights into how TRAP contributes to asthma.
  • Accurate quantification of TRAP exposure requires advanced assessment techniques.
  • Heterogeneity in TRAP exposure definitions and asthma outcomes has previously caused confusion.

Conclusions:

  • Novel molecular and epigenetic data are revolutionizing the understanding of TRAP and asthma.
  • Integrating new findings on phenotypes, exposure assessment, and epigenetics will accelerate research.
  • These advancements are vital for developing effective interventions against TRAP-induced asthma.