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Accelerated partial breast irradiation: Past, present, and future.

Anne W Tann¹, Sandra S Hatch¹, Melissa M Joyner¹

¹Anne W Tann, Sandra S Hatch, Melissa M Joyner, Lee R Wiederhold, Todd A Swanson, Department of Radiation Oncology, the University of Texas Medical Branch, Galveston, TX 77555-0711, United States.

World Journal of Clinical Oncology

|October 26, 2016

Summary

This summary is machine-generated.

Accelerated partial breast irradiation (APBI) offers a shorter radiation schedule for early-stage breast cancer, showing promising cosmetic and local control outcomes. Ongoing trials will refine patient selection for this breast conserving therapy.

Keywords:

Accelerated partial breast irradiation Breast cancer Interstitial brachytherapy Intracavitary brachytherapy

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Area of Science:

Oncology
Radiation Oncology

Background:

Accelerated partial breast irradiation (APBI) is increasingly used for early-stage breast cancer due to shorter treatment times and positive outcomes.
Advances in APBI technologies have improved accessibility in community settings.

Approach:

This review provides an overview of clinical and cosmetic outcomes for various APBI techniques.
It examines current guidelines for patient selection in breast conserving therapy.
The economic impact and patient-reported quality of life associated with APBI are also discussed.

Key Points:

APBI utilizes higher radiation doses over a shorter interval to the lumpectomy cavity.
Positive cosmetic outcomes and high local control rates are observed in selected patients.
Technological advancements have expanded the availability of APBI modalities.

Conclusions:

Ongoing clinical trials are crucial for identifying optimal candidates for APBI.
Long-term results will further guide the selection of patients who can benefit most from this approach.
Understanding the impact on healthcare economics and patient quality of life is essential.