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Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
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Von Willebrand factor and angiogenesis: basic and applied issues.

A M Randi1, M A Laffan2

  • 1National Heart and Lung Institute, Imperial College, London, UK.

Journal of Thrombosis and Haemostasis : JTH
|October 26, 2016
PubMed
Summary
This summary is machine-generated.

Von Willebrand factor (VWF) regulates blood vessel formation. Loss of VWF in endothelial cells (EC) enhances angiogenesis, potentially causing vascular malformations and gastrointestinal bleeding in von Willebrand disease (VWD).

Keywords:
VEGF receptor-2angiodysplasiaangiopoietin-2endothelial cellshemostasis

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Area of Science:

  • Vascular Biology
  • Hemostasis
  • Angiogenesis

Background:

  • Von Willebrand factor (VWF) is traditionally known for its role in hemostasis.
  • Recent research reveals novel functions for VWF beyond blood clotting.
  • VWF is synthesized in megakaryocytes and endothelial cells (EC).

Purpose of the Study:

  • To review evidence for VWF's role in blood vessel formation (angiogenesis).
  • To explore the link between VWF dysfunction, vascular malformations, and gastrointestinal (GI) bleeding.
  • To discuss potential novel therapeutic strategies for VWD-related bleeding.

Main Methods:

  • In vitro and in vivo studies investigating VWF's role in angiogenesis.
  • Isolation of EC from peripheral blood progenitors of normal controls and VWD patients.
  • Analysis of molecular pathways regulated by VWF.

Main Results:

  • Loss of VWF in EC leads to enhanced, potentially dysfunctional, angiogenesis.
  • This finding aligns with clinical observations of vascular malformations causing GI bleeding in some VWD patients.
  • VWF influences angiogenesis through multiple intracellular and extracellular pathways.

Conclusions:

  • VWF plays a significant role in regulating blood vessel formation.
  • VWF dysfunction is linked to vascular malformations and GI bleeding in VWD.
  • Understanding these pathways may lead to new treatments for refractory bleeding in VWD.