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TNFAIP3 gene rs10499194, rs13207033 polymorphisms decrease the risk of rheumatoid arthritis.

Ming-Jie Wang1, Hao-Yu Yang1, Hui Zhang1

  • 1Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou, China.

Oncotarget
|October 26, 2016
PubMed
Summary
This summary is machine-generated.

Genetic variations in the TNFAIP3 gene, specifically rs10499194 and rs13207033, are linked to a reduced risk of rheumatoid arthritis (RA). This protective effect is particularly notable in Caucasian populations.

Keywords:
TNFAIP3meta-analysisrheumatoid arthritissingle nucleotide polymorphism

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Area of Science:

  • Genetics
  • Immunology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • The tumor necrosis factor alpha inducible protein 3 (TNFAIP3) gene plays a role in immune regulation.
  • Previous studies on TNFAIP3 gene polymorphisms (rs10499194, rs13207033) and RA risk have shown conflicting results.

Purpose of the Study:

  • To conduct a comprehensive meta-analysis to clarify the association between TNFAIP3 gene rs10499194, rs13207033 polymorphisms and rheumatoid arthritis risk.
  • To evaluate the influence of ethnicity on this association.

Main Methods:

  • A systematic literature search was performed in PubMed, Embase, and the China Knowledge Resource Integrated Database.
  • Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed-effect or random-effect models.
  • Included 13 case-control studies for rs10499194 and 6 studies for rs13207033.

Main Results:

  • The meta-analysis indicated that TNFAIP3 gene rs10499194 and rs13207033 polymorphisms are associated with a decreased risk of RA.
  • Stratification by ethnicity revealed that these polymorphisms decrease RA risk in Caucasian populations.
  • No significant association was found in Asian populations.

Conclusions:

  • TNFAIP3 gene rs10499194 and rs13207033 polymorphisms are associated with a reduced risk of rheumatoid arthritis.
  • The protective effect of these polymorphisms against RA is more pronounced in Caucasian individuals.