Relationship between Inflammatory Response and Estimated Complication Rate after Total Hip Arthroplasty

Area of Science:

• Orthopedic Surgery
• Inflammatory Response
• Biomarkers

Background:

• Total hip arthroplasty (THA) triggers a significant inflammatory response, impacting recovery and complication rates.
• Limited research exists on the direct link between early inflammatory markers and postoperative complications after THA.

Purpose of the Study:

• To investigate the early inflammatory response within 72 hours post-THA.
• To determine the relationship between inflammatory markers and the estimated complication rate after THA.

Main Methods:

• Prospective cohort study of 148 patients undergoing unilateral THA.
• Measured C-reactive protein (CRP) and interleukin-6 (IL-6) levels at 24, 48, and 72 hours post-surgery.
• Utilized the POSSUM score to estimate complication rates and the Harris score for hip function assessment.

Main Results:

• IL-6 peaked at 24 hours, CRP at 48 hours post-THA, with subsequent decreases.
• Peak CRP and IL-6 levels positively correlated with the estimated complication rate (P<0.001).
• Patients with complications showed significantly higher peak CRP and IL-6 levels compared to those without (P<0.001).

Conclusions:

• Peak CRP and IL-6 levels are significantly associated with an increased estimated complication rate after THA.
• Early inflammatory response markers can effectively predict the incidence of postoperative complications following total hip arthroplasty.