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Related Experiment Video

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Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Thyroid Dysfunction in Primary Biliary Cholangitis: A Comparative Study at Two European Centers.

Annarosa Floreani1, Chiara Mangini1, Anna Reig2

  • 1Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

The American Journal of Gastroenterology
|October 26, 2016
PubMed
Summary
This summary is machine-generated.

Thyroid disease (TD) is common in primary biliary cholangitis (PBC) patients, particularly autoimmune forms like Hashimoto's thyroiditis. However, the presence of TD does not impact PBC progression or liver-related outcomes.

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Area of Science:

  • Hepatology
  • Endocrinology
  • Autoimmunology

Background:

  • Primary biliary cholangitis (PBC) frequently co-occurs with other autoimmune conditions.
  • The impact of co-existing thyroid disease (TD) on the natural history of PBC remains largely uncharacterized.

Purpose of the Study:

  • To investigate the association between primary biliary cholangitis and thyroid disease.
  • To evaluate the influence of thyroid disease on the clinical progression and outcomes of primary biliary cholangitis.

Main Methods:

  • A retrospective analysis of 921 primary biliary cholangitis patients from two European centers (Padova and Barcelona) between 1975 and 2015.
  • Data collected included histological stage, biochemical markers, associated autoimmune conditions, and clinical events like hepatic decompensation.
  • Patients were monitored for a mean follow-up of approximately 127 months.

Main Results:

  • 16.3% of PBC patients had a concurrent thyroid disease diagnosis.
  • Hashimoto's thyroiditis was the most common TD (10.2%), followed by Graves' disease (1.6%) and multinodular goiter (2.4%).
  • No significant differences were observed in histological stage, hepatic decompensation, hepatocellular carcinoma (HCC) rates, or liver transplantation rates between PBC patients with and without TD. Survival rates were also unaffected by the presence of TD.

Conclusions:

  • Thyroid diseases, including autoimmune variants like Hashimoto's thyroiditis, are frequently observed in patients with primary biliary cholangitis.
  • The presence of co-existing thyroid disease does not appear to adversely affect the rate of hepatic complications or alter the natural disease course of primary biliary cholangitis.