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Infratentorial congenital glioblastoma multiforme. A rare tumour with a still unknown biology
Introduction:
Congenital glioblastoma multiforme represents only 3% of congenital central nervous system tumours and an infratentorial location is unusual.
Case Report:
A newborn with congenital glioblastoma multiforme with no mutation in the TP53 gene or p53 nuclear immunoreactivity that infiltrated practically the whole brainstem and also invaded supratentorial structures.
Conclusions:
As far as we know, only four cases with an infratentorial location have been reported previously, three in the cerebellum and one in the brainstem. The biology of congenital glioblastoma multiforme is not well known and, unlike glioblastoma multiforme in adults and children, mutations in the TP53 gene are uncommon. However, this is not associated with a more favourable prognosis. These observations suggest that specific biological processes underlie fetal glioblastoma multiforme development.
