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Discovery to Development: Insecticides for Malaria Vector Control.

James A Turner1, Colin N E Ruscoe2, Trevor R Perrior2

  • 1PO Box 683728 Park City, UT 84068, USA; Public Health External Scientific Advisory Committee Innovative Vector Control Consortium Liverpool School of Tropical Medicine Pembroke Place Liverpool L3 5QA, UK. turnerja1@q.com.

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Summary

Discovering new insecticides is crucial for malaria vector control. This program outlines a discovery cascade, using a Target Product Profile (TPP), to develop novel agents with diverse modes of action.

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Area of Science:

  • Public Health
  • Entomology
  • Chemical Biology

Background:

  • Current malaria vector control agents face challenges due to resistance and limited modes of action.
  • There is a critical need for new chemical insecticides with novel mechanisms to combat malaria vectors effectively.

Purpose of the Study:

  • To outline a comprehensive program for the discovery of new public health insecticides for malaria vector control.
  • To establish a discovery cascade based on the Innovative Vector Control Consortium (IVCC) New Active Ingredient Target Product Profile (TPP).

Main Methods:

  • Review of current vector control agents' properties to identify gaps.
  • Development of a discovery cascade with experimental stages for chemical screening and candidate profiling.
  • Implementation of a staged development system for guiding insecticide discovery programs.

Main Results:

  • The report details a structured approach for identifying and developing new insecticide candidates.
  • The proposed cascade systematically evaluates chemicals against TPP requirements from screening to pre-development.

Conclusions:

  • A systematic discovery program, guided by a TPP and a staged development process, is essential for advancing new malaria vector control agents.
  • This framework aims to accelerate the development of effective insecticides with diverse modes of action to overcome resistance and improve malaria control outcomes.