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Updated: Mar 13, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
VEGF gene polymorphisms and outcome of epithelial ovarian cancer patients
Gabriela Ribeiro Camerin1, Angelo Borsarelli Carvalho Brito2, José Vassallo3
1Faculty of Medicine, Pontifical Catholic University of Campinas, Campinas, São Paulo, Brazil.
Aim:
Since VEGF polymorphisms were associated with variable protein production, we analyzed herein their roles in outcome of epithelial ovarian cancer (EOC) patients.
Methods:
Genotypes of 85 patients with primary EOC were identified in DNA by real-time PCR. Progression-free survival and overall survival were analyzed using Kaplan-Meier method, univariate Cox model and bootstrap resampling study.
Results:
At 60 months of follow-up, progression-free survival was shorter in patients with VEGF c.-2578 CC genotype compared with others (52.7 vs 82.2%; p = 0.04). Those patients had 2.15 more chance of presenting disease progression than others (p = 0.04); bootstrap study validated the result (p = 0.03).
Conclusion:
Our data suggest that VEGF c.-2578C>A polymorphism acts as a prognostic factor in EOC.
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