FutureTox III: Bridges for Translation

Area of Science:

• Toxicology
• Risk Assessment
• Computational Biology

Background:

• The Society of Toxicology's Future Tox III workshop convened to discuss advancements in risk assessment.
• Building on previous workshops, the focus was on integrating new data sources and models.

Purpose of the Study:

• To assess progress in implementing a big-data toolbox for risk assessment.
• To explore challenges and opportunities in predictive toxicology for regulatory decision-making.

Main Methods:

• The workshop synthesized discussions on in vitro data and in silico models.
• Case studies highlighted applications within federal agencies.

Main Results:

• Advancements in predictive toxicology are being applied in federal agencies.
• Opportunities exist for integrating exposome and Adverse Outcome Pathway (AOP) domains.
• Bridging historical methods with new approaches like Tox21 is crucial.

Conclusions:

• The toxicology community is making progress in adopting big-data tools for risk assessment.
• Continued collaboration is needed to translate new scientific approaches into regulatory practice.