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Survival at 2 years among liver cirrhotic patients is influenced by left atrial volume and left ventricular mass

Manuela Merli1, Concetta Torromeo2, Michela Giusto1

  • 1Gastroenterology, Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.

Liver International : Official Journal of the International Association for the Study of the Liver
|October 27, 2016
PubMed

Insights

Cirrhotic cardiomyopathy (CC) can be predicted by cardiac parameters. Increased left atrial volume (LAVi) and decreased left ventricular mass (LVMi) indicate higher mortality risk in cirrhosis patients.

Area of Science:

  • Cardiology
  • Hepatology
  • Echocardiography

Background:

  • Cirrhotic cardiomyopathy (CC) complicates advanced liver disease and impacts patient outcomes.
  • Identifying reliable markers for reduced cardiac reserve in cirrhosis remains challenging.
  • Doppler echocardiography offers potential for prognostic assessment in cirrhotic patients.

Purpose of the Study:

  • To identify Doppler echocardiography-derived cardiac parameters predictive of survival in cirrhotic patients.
  • To evaluate left atrial volume index (LAVi) and left ventricular mass index (LVMi) as prognostic markers.
  • To compare novel parameters with existing criteria for CC diagnosis.

Main Methods:

  • Ninety stable cirrhotic patients without cardiovascular or pulmonary disease were enrolled.
  • Doppler echocardiography was used to assess cardiac parameters, including LAVi and LVMi.
  • Patients were followed for at least 24 months to determine survival outcomes.

Main Results:

  • Overall mortality was 26.7% over 24 months.
  • Higher LAVi (P=.04) and lower LVMi (P=.007) were significantly associated with increased mortality risk.
  • No significant survival difference was observed based on the Montreal criteria diagnosis of CC.

Conclusions:

  • Increased LAVi and decreased LVMi are valuable predictors of 2-year survival in cirrhotic patients.
  • These echocardiographic parameters should be incorporated into prognostic evaluations for cirrhosis.
  • Current criteria for CC diagnosis may not fully capture survival risks.
Abstract

Keywords:
cirrhosiscirrhotic cardiomyopathyprognosis

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