Communication: A multiscale Bayesian inference approach to analyzing subdiffusion in particle trajectories
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Updated: Mar 13, 2026

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
Published on: September 5, 2019
Konrad Hinsen1, Gerald R Kneller1
1Centre de Biophysics. Moléculaire, CNRS, Rue Charles Sadron, 45071 Orléans, France.
Abstract:
Anomalous diffusion is characterized by its asymptotic behavior for t → ∞. This makes it difficult to detect and describe in particle trajectories from experiments or computer simulations, which are necessarily of finite length. We propose a new approach using Bayesian inference applied directly to the observed trajectories sampled at different time scales. We illustrate the performance of this approach using random trajectories with known statistical properties and then use it for analyzing the motion of lipid molecules in the plane of a lipid bilayer.
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