Related Experiment Video
Updated: Mar 13, 2026
09:34
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
9.5K
Oleanane derivatives for pharmaceutical use: a patent review (2000-2016).
Milena Masullo1, Cosimo Pizza1, Sonia Piacente1
1a Dipartimento di Farmacia , Università degli Studi di Salerno , Fisciano , Italy.
Expert Opinion on Therapeutic Patents
|October 27, 2016
Summary
Oleanane triterpenoids show promise in treating inflammation and cancer, but clinical trials revealed safety concerns. Oleanane saponins may be valuable as vaccine adjuvants.
Area of Science:
- Natural Product Chemistry
- Medicinal Chemistry
- Pharmacology
Background:
- Oleanolic acid serves as a versatile starting material for synthesizing numerous oleanane triterpenoids.
- Patents highlight the biological activities and pharmaceutical potential of synthesized oleanane derivatives and oleanane-type saponins.
Purpose of the Study:
- To review patents on the biological activities of oleanane derivatives and saponins.
- To assess the therapeutic potential and challenges of these compounds in drug development.
Main Methods:
- Examination of patent literature concerning oleanane derivatives and saponins.
- Analysis of reported biological activities, including anti-inflammatory, anti-proliferative, and adjuvant properties.
Main Results:
- 2-cyano-3,12-dioxoolean-1,9(11)-dien-28-oic acid derivatives show potential in modulating inflammation, oxidative stress, and cell proliferation.
- Oleanane-type saponins are patented for antiproliferative effects and as vaccine adjuvants.
- CDDO-Me, an oleanane derivative, faced clinical trial termination due to adverse effects, though further trials are ongoing.
Conclusions:
- Further research is needed to develop oleanane derivatives with improved activity and safety profiles for therapeutic use.
- Oleanane-type saponins hold significant promise as adjuvants in vaccine formulations.
Related Concept Videos
01:17Drug Nomenclature
3.6K
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
3.6K
01:22Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
235
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
235
01:28Structure-Activity Relationships and Drug Design
1.9K
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
1.9K
01:25Drug Regulation
3.2K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
3.2K
01:19Antiasthma Drugs: Leukotriene Modifiers
2.1K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
2.1K
01:26FDA Approved Drugs: Changes to Approved Drugs
311
Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
311