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NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription

Dalei Wu1, Xiaoyu Su1, Nalini Potluri1

  • 1Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, United States.

Elife
|October 27, 2016
PubMed

Keywords:
Hypoxia-Inducible FactorNeuronal PAS ProteinsPAS domainsbHLH-PAS proteinsbiophysicscrystal structuredrug discoveryhumanligand binding pocketsmousepsychiatric disordersstructural biologytranscription factor

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