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Related Experiment Video

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis.

Xin Tan1, Peng Fang2, Jie An1

  • 1Medical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.

Neuroradiology
|October 27, 2016
PubMed
Summary

Type 2 diabetes mellitus (T2DM) is linked to white matter (WM) abnormalities in the brain, similar to those seen in Alzheimer's disease (AD). This study reveals specific WM regions affected in T2DM patients, offering insights into neuropathology.

Keywords:
Default mode networkDiffusion tensor imagingThalamusTract-based spatial statisticsType 2 diabetes mellitus

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Area of Science:

  • Neuroimaging
  • Neurology
  • Endocrinology

Background:

  • Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment and brain white matter (WM) abnormalities.
  • Previous studies show varied findings, and the relationship between T2DM and Alzheimer's disease (AD) remains unclear.

Purpose of the Study:

  • To assess whole-brain WM integrity in T2DM patients.
  • To compare WM abnormalities in T2DM with those reported in AD cases.

Main Methods:

  • Diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) were used.
  • 48 T2DM patients and 48 healthy controls were analyzed.
  • The influence of age and gender was evaluated.

Main Results:

  • Significant decreases in fractional anisotropy (FA) and increases in mean diffusivity (MD) and diffusivity anisotropy (DA) were observed in T2DM patients (P<0.05).
  • Affected WM regions include those related to the default mode network (DMN), such as the cingulum, uncinate fasciculus (UF), superior longitudinal fasciculus (SLF), and inferior longitudinal fasciculus (ILF).
  • Abnormalities were also found in the thalamus, affecting the fornix (FX), anterior thalamic radiation (ATR), and posterior thalamic radiation (PTR), mirroring findings in AD.

Conclusions:

  • The study identifies specific WM regions and tracts impacted by T2DM.
  • Findings provide insights into the neuropathological processes in T2DM.
  • The results suggest a relationship between T2DM and AD neuropathology.