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Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases
Published on: December 9, 2022
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Anti-angiogenic Therapy for Retinal Disease
Yannis M Paulus1, Akrit Sodhi2
1Kellogg Eye Center, University of Michigan School of Medicine, 1000 Wall Street, Ann Arbor, MI, 48105, USA.
Handbook of Experimental Pharmacology
|October 27, 2016
Summary
Targeting vascular endothelial growth factor (VEGF) has revolutionized retinal vascular disease treatment. Anti-VEGF therapies are crucial for managing conditions like diabetic eye disease and retinal vein occlusions, with ongoing research exploring new applications.
Area of Science:
- Ophthalmology
- Molecular Biology
- Pharmacology
Background:
- Retinal vascular diseases are driven by pathological angiogenesis and vascular hyperpermeability.
- Vascular Endothelial Growth Factor (VEGF) is a key mediator in these processes.
- Hypoxia-inducible factors (HIFs) regulate the expression of angiogenic factors.
Purpose of the Study:
- To review the molecular pathophysiology of retinal vascular diseases.
- To discuss current anti-angiogenic pharmacotherapies targeting VEGF.
- To explore future directions in retinal vascular disease treatment.
Main Methods:
- Review of current literature on retinal vascular disease.
- Analysis of the role of VEGF and HIFs in angiogenesis.
- Evaluation of anti-VEGF therapies and their applications.
Main Results:
- Anti-VEGF therapies have significantly improved outcomes for conditions like age-related macular degeneration, diabetic macular edema, and retinal vein occlusions.
- VEGF-targeting therapies show promise for diabetic retinopathy and retinopathy of prematurity.
- Understanding HIFs provides further targets for therapeutic intervention.
Conclusions:
- Targeting VEGF is a cornerstone in managing retinal vascular diseases.
- Expanding anti-VEGF therapy applications is supported by emerging evidence.
- Future research may focus on HIF-mediated pathways for novel treatments.
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